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Literature summary for 5.6.1.7 extracted from
- Chaperonin overexpression promotes genetic variation and enzyme evolution (2009), Nature, 459, 668-673.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GroEL/GroES | - |
Escherichia coli |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Escherichia coli | GroEL/GroES overexpression doubles the number of accumulating mutations, and promotes the folding of enzyme variants carrying mutations in the protein core and/or mutations with higher destabilizing effects | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | protein stability is a major constraint in protein evolution. Buffering mechanisms such as chaperonins are key in alleviating this constraint | Escherichia coli |
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