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Literature summary for 5.6.1.7 extracted from
- Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm-cpn (2003), FEBS Lett., 547, 201-204.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | approx. 40% inhibition at 20 mM, 93% inhibition at 100 mM | Methanococcus maripaludis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | positive intraring cooperativity of ATP is suggested | Methanococcus maripaludis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | required for activity, no activity below 10 mM, maximal activity at 600 mM | Methanococcus maripaludis | |
| Mg2+ | required for activity, similar activation between 1 and 50 mM | Methanococcus maripaludis | |
| NH4+ | 200 mM, approx. 40% of activity with 200 mM KCl | Methanococcus maripaludis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + a folded polypeptide | Methanococcus maripaludis | - |
ADP + phosphate + an unfolded polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanococcus maripaludis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Methanococcus maripaludis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + a folded polypeptide | - |
Methanococcus maripaludis | ADP + phosphate + an unfolded polypeptide | - |
? | |
| ATP + H2O + a folded polypeptide | Mm-cpn also hydrolyzes with slightly weaker activity CTP, UTP and GTP | Methanococcus maripaludis | ADP + phosphate + an unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Mm-cpn | - |
Methanococcus maripaludis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Methanococcus maripaludis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | almost no activity at pH 6.0, approx. 90% of maximal activity at pH 9.0 | Methanococcus maripaludis |
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