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Literature summary for 5.6.1.7 extracted from

  • Taguchi H.; Konishi, J.; Ishi, N.; Yoshida, M.
    A chaperonin from a thermophilic bacterium, Thermus thermophilus, that controls refoldings of several thermophilic enzymes (1991), J. Biol. Chem., 266, 22411-22418.
    View publication on PubMed
Search for more literature for 5.6.1.7

Activating Compound

Activating Compound Comment Organism Structure
NaHCO3 200 mM, 2.15fold increase in activity Thermus thermophilus

Inhibitors

Inhibitors Comment Organism Structure
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole 0.1 mM, 31% inhibition Thermus thermophilus
Dicyclohexylcarbodiimide 0.1 mM, 43% inhibition Thermus thermophilus
N-ethylmaleimide 0.1 mM, 32% inhibition Thermus thermophilus
Na2SO3 200 mM, 86% inhibition Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a folded polypeptide Thermus thermophilus
-
 ADP + phosphate + an unfolded polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
 thermophilic bacterium
-

Purification (Commentary)

Purification (Comment) Organism
gel filtration Thermus thermophilus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.1
-
 at 80°C Thermus thermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a folded polypeptide
-
 Thermus thermophilus ADP + phosphate + an unfolded polypeptide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
80
-
-
 Thermus thermophilus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
60 90 no or very little activity below 40°C Thermus thermophilus