Literature summary for 5.6.1.6 extracted from

Ehrhardt, A.; Chung, W.J.; Pyle, L.C.; Wang, W.; Nowotarski, K.; Mulvihill, C.M.; Ramjeesingh, M.; Hong, J.; Velu, S.E.; Lewis, H.A.; Atwell, S.; Aller, S.; Bear, C.E.; Lukacs, G.L.; Kirk, K.L.; Sorscher, E.J.
Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop (2016), J. Biol. Chem., 291, 1854-1865 .

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Protein Variants

Protein Variants	Comment	Organism
F508del	the mutation is associated with cystic fibrosis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
CL1 peptide	both intrinsic ATPase activity and channel gating are inhibited severely by CL1 peptide	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + closed Cl- channel	Homo sapiens	-	ADP + phosphate + open Cl- channel	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + closed Cl- channel	-	Homo sapiens	ADP + phosphate + open Cl- channel	-	?

Synonyms

Synonyms	Comment	Organism
CFTR	-	Homo sapiens
cystic fibrosis transmembrane conductance regulator	-	Homo sapiens

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Release 2023.1 (January 2023)