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Literature summary for 5.6.1.6 extracted from

  • Zwick, M.; Esposito, C.; Hellstern, M.; Seelig, A.
    How phosphorylation and ATPase activity regulate anion flux though the cystic fibrosis transmembrane conductance regulator (CFTR) (2016), J. Biol. Chem., 291, 14483-14498 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Activating Compound

Activating Compound Comment Organism Structure
8-(4-chlorophenylthio)-AMP the ATPase activity of the enzyme is enhanced in the presence of very low concentrations of 8-(4-chlorophenylthio)-AMP Homo sapiens
additional information the ATPase activity of the enzyme is enhanced by anion channel inhibitors including glibenclamide, glipizide, and CFTRinh-172 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Chinese hamster ovary and baby hamster kidney cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E1371S the mutant has no ATPase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
8-(4-chlorophenylthio)-AMP the ATPase activity of the enzyme is reduced in the presence of higher concentrations of 8-(4-chlorophenylthio)-AMP Homo sapiens
CFTRinh-172 i.e., 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]4-thiazolidinone Homo sapiens
glibenclamide
-
 Homo sapiens
glipizide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed I- channel Homo sapiens
-
 ADP + phosphate + open I- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation by protein kinase A occurs in the post-hydrolysis transition state of the enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed I- channel
-
 Homo sapiens ADP + phosphate + open I- channel
-
 ?

Synonyms

Synonyms Comment Organism
ABCC7
-
 Homo sapiens
CFTR
-
 Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
14
-
 ATP partially phosphorylated enzyme, at pH 7.4 and 37°C Homo sapiens