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Literature summary for 5.6.1.6 extracted from

  • Wei, S.; Roessler, B.C.; Icyuz, M.; Chauvet, S.; Tao, B.; Hartman, J.L.; Kirk, K.L.
    Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels (2016), FASEB J., 30, 1247-1262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F337A the mutation exhibits strong gain of function effects Homo sapiens
F337C the mutation exhibits strong gain of function effects Homo sapiens
F337L the mutation exhibits strong gain of function effects Homo sapiens
F337S the mutation exhibits strong gain of function effects and markedly increases the activities of enzyme constructs that cannot be activated by ATP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens
phosphoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
CFTR
-
 Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens