Cloned (Comment) | Organism |
---|---|
quantitative PCR-based enzyme expression analysis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of the enzyme with inhibitor CFTRinh172 and transfection with CFTR-specific siRNAs in DC2 cells reduces basal and forskolin-activated ATP release | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
x * 160000, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P26361 | - |
- |
Mus musculus C57BL/6 | P26361 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cauda epididymis | - |
Mus musculus | - |
epithelial cell | primary cultures of epididymal epithelial cells | Mus musculus | - |
plasmacytoid T-lymphocyte | an immortalized epididymal cell line, quantitative enzyme expression analysis, overview | Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 160000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition or knockdown of CFTR inhibits ATP release from mouse epididymal principal cells. Inhibition of CFTR reduces ATP release into the lumen of cauda epididymis in mice in vivo. Defective ATP signalling in the epididymis might contribute to dysfunction of the male reproductive tract associated with CFTR mutations. Given that mutations in CFTR are a leading cause of male infertility, defective ATP signalling in the epididymis might contribute to dysfunction of the male reproductive tract associated with these mutations | Mus musculus |
physiological function | involvement of the enzyme in the regulation of ATP release from epithelial principal cells in the cauda epididymidis, ATP secretion into the lumen of the cauda epididymal tubule. Extracellular ATP is a key modulator of epididymal function, regulating both transepithelial transport | Mus musculus |