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Literature summary for 5.6.1.6 extracted from

  • Ruan, Y.C.; Shum, W.W.; Belleannee, C.; Da Silva, N.; Breton, S.
    ATP secretion in the male reproductive tract: essential role of CFTR (2012), J. Physiol., 590, 4209-4222.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
quantitative PCR-based enzyme expression analysis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of the enzyme with inhibitor CFTRinh172 and transfection with CFTR-specific siRNAs in DC2 cells reduces basal and forskolin-activated ATP release Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
x * 160000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P26361
-
-
Mus musculus C57BL/6 P26361
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cauda epididymis
-
Mus musculus
-
epithelial cell primary cultures of epididymal epithelial cells Mus musculus
-
plasmacytoid T-lymphocyte an immortalized epididymal cell line, quantitative enzyme expression analysis, overview Mus musculus
-

Subunits

Subunits Comment Organism
? x * 160000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
CFTR
-
Mus musculus

General Information

General Information Comment Organism
malfunction inhibition or knockdown of CFTR inhibits ATP release from mouse epididymal principal cells. Inhibition of CFTR reduces ATP release into the lumen of cauda epididymis in mice in vivo. Defective ATP signalling in the epididymis might contribute to dysfunction of the male reproductive tract associated with CFTR mutations. Given that mutations in CFTR are a leading cause of male infertility, defective ATP signalling in the epididymis might contribute to dysfunction of the male reproductive tract associated with these mutations Mus musculus
physiological function involvement of the enzyme in the regulation of ATP release from epithelial principal cells in the cauda epididymidis, ATP secretion into the lumen of the cauda epididymal tubule. Extracellular ATP is a key modulator of epididymal function, regulating both transepithelial transport Mus musculus