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Literature summary for 5.6.1.6 extracted from

  • Shimizu, H.; Yu, Y.C.; Kono, K.; Kubota, T.; Yasui, M.; Li, M.; Hwang, T.C.; Sohma, Y.
    A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR (2010), J. Physiol. Sci., 60, 353-362.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y1219F mutation at NBD2, decreases ATP binding affinity and significantly increases the prevalence of the long-lasting opening events with a time constant of tens of seconds Homo sapiens
Y1219G mutation at NBD2, decreases ATP binding affinity and significantly increases the prevalence of the long-lasting opening events with a time constant of tens of seconds Homo sapiens
Y1219I mutation at NBD2, decreases ATP binding affinity and significantly increases the prevalence of the long-lasting opening events with a time constant of tens of seconds Homo sapiens
Y1219W mutation at NBD2, decreases ATP binding affinity and significantly increases the prevalence of the long-lasting opening events with a time constant of tens of seconds Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a stable binding of ATP to NBD2 is required forthe normal, fast gating cycle of CFTR channel, and instability of ATP binding frequently halts the CFTR gating cycle in the open state presumably through a slowdown of ATP hydrolysis at NBD2 Homo sapiens ?
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