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Literature summary for 5.6.1.6 extracted from

  • Bai, Y.; Li, M.; Hwang, T.C.
    Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7) (2011), J. Gen. Physiol., 138, 495-507.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of a construct lacking Cys-residues, in CHO-cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information introduction of cysteine resiudues to a Cys-less mutant and cysteine scanning of TM12 of CFTR using intracellularly applied 2-sulfonatoethyl methanethiosulfonate reagents. Data show high reaction rates of substituted cysteines toward the probes, strong blocker protection of cysteines against reaction, and reaction-induced alterations in channel conductance, supporting the idea that TM12 of CFTR contributes to the lining of the ion permeation pathway Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + closed Cl- channel = ADP + phosphate + open Cl- channel upon channel opening, the wide cytoplasmic vestibule tightens and the pore-lining TM12 rotates along its helical axis Homo sapiens

Synonyms

Synonyms Comment Organism
ABCC7
-
Homo sapiens