Literature summary for 5.6.1.6 extracted from

Kelly, M.; Trudel, S.; Brouillard, F.; Bouillaud, F.; Colas, J.; Nguyen-Khoa, T.; Ollero, M.; Edelman, A.; Fritsch, J.
Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition (2010), J. Pharmacol. Exp. Ther., 333, 60-69.

Search for more literature for 5.6.1.6

Inhibitors

Inhibitors	Comment	Organism	Structure
3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone	CFTR(inh)-172, potent CFTR inhibitor, exerts nonspecific effects regarding reactive oxygen species production, mitochondrial failure, and activation of the NF-kappa B signaling pathway, independently of CFTR inhibition	Homo sapiens
N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide	GlyH-101, potent CFTR inhibitor, exerts nonspecific effects regarding reactive oxygen species production, mitochondrial failure, and activation of the NF-kappa B signaling pathway, independently of CFTR inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
CFTR	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)