Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.1.6 extracted from

  • Barriere, H.; Bagdany, M.; Bossard, F.; Okiyoneda, T.; Wojewodka, G.; Gruenert, D.; Radzioch, D.; Lukacs, G.L.
    Revisiting the role of CFTR and counterion permeability in the pH regulation of endocytic organelles (2009), Mol. Biol. Cell, 20, 3125-3141.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the 3HA-tagged wild-type enzyme as well as of mutant G551D CFTR and mutant DELTAF508 CFTR in BHK, CFBE and HeLa cells Homo sapiens
transient expression of CFTR in RAW macrophages Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information CFTR complementation of cystic fibrosis respiratory epithelia has no effect on the endosomal pH Mus musculus
additional information introduction of an extracellular 3HA-tag, consisting of amino acid residues of SLEYPYDVPDYASYPYDVPDYAYPYDVPD, into the 4th extracellular loop after residue 897 in the G551D CFTR mutant and the wild-type enzyme as well as into the mutant DELTAF508 CFTR. Heterologous overexpression fails to alter endocytic organellar pH Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome recycling Mus musculus 5768
-
endosome recycling Homo sapiens 5768
-
membrane
-
Mus musculus 16020
-
membrane
-
Homo sapiens 16020
-
additional information the wild-type and G551D CFTR have overlapping postendocytic membrane trafficking. G551D like its wild-type counterpart recycles back to the cell surface and largely avoids lysosomal delivery Homo sapiens
-
-
phagosome immature Homo sapiens
-
-
phagosome immature, internalized CFTR traverses the immature phagosome Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease ?
-
?
additional information Mus musculus neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease, effect of CFTR deficiency in genetically matched respiratory epithelia and alveolar macrophages, overview. CFTR-independent endosomal and phagosomal acidification occurs in RAW macrophages ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium respiratory epithelia Mus musculus
-
epithelium respiratory epithelia Homo sapiens
-
lung respiratory epithelia Mus musculus
-
lung respiratory epithelia Homo sapiens
-
macrophage peritoneal Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease Homo sapiens ?
-
?
additional information neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease, effect of CFTR deficiency in genetically matched respiratory epithelia and alveolar macrophages, overview. CFTR-independent endosomal and phagosomal acidification occurs in RAW macrophages Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
CFTR
-
Mus musculus
CFTR
-
Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
Mus musculus
cystic fibrosis transmembrane conductance regulator
-
Homo sapiens