Cloned (Comment) | Organism |
---|---|
overexpression of the 3HA-tagged wild-type enzyme as well as of mutant G551D CFTR and mutant DELTAF508 CFTR in BHK, CFBE and HeLa cells | Homo sapiens |
transient expression of CFTR in RAW macrophages | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | CFTR complementation of cystic fibrosis respiratory epithelia has no effect on the endosomal pH | Mus musculus |
additional information | introduction of an extracellular 3HA-tag, consisting of amino acid residues of SLEYPYDVPDYASYPYDVPDYAYPYDVPD, into the 4th extracellular loop after residue 897 in the G551D CFTR mutant and the wild-type enzyme as well as into the mutant DELTAF508 CFTR. Heterologous overexpression fails to alter endocytic organellar pH | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | recycling | Mus musculus | 5768 | - |
endosome | recycling | Homo sapiens | 5768 | - |
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
additional information | the wild-type and G551D CFTR have overlapping postendocytic membrane trafficking. G551D like its wild-type counterpart recycles back to the cell surface and largely avoids lysosomal delivery | Homo sapiens | - |
- |
phagosome | immature | Homo sapiens | - |
- |
phagosome | immature, internalized CFTR traverses the immature phagosome | Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease | ? | - |
? | |
additional information | Mus musculus | neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease, effect of CFTR deficiency in genetically matched respiratory epithelia and alveolar macrophages, overview. CFTR-independent endosomal and phagosomal acidification occurs in RAW macrophages | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | respiratory epithelia | Mus musculus | - |
epithelium | respiratory epithelia | Homo sapiens | - |
lung | respiratory epithelia | Mus musculus | - |
lung | respiratory epithelia | Homo sapiens | - |
macrophage | peritoneal | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease | Homo sapiens | ? | - |
? | |
additional information | neither channel activation nor inhibition influence the pH in recycling endosomes nor immature phagosomes. Perturbations of the endo-lysosomal organelles pH homeostasis cannot be linked to the etiology of the cystic fibrosis lung disease, effect of CFTR deficiency in genetically matched respiratory epithelia and alveolar macrophages, overview. CFTR-independent endosomal and phagosomal acidification occurs in RAW macrophages | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Mus musculus |
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Mus musculus |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |