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Literature summary for 5.6.1.6 extracted from

  • Huang, S.Y.; Bolser, D.; Liu, H.Y.; Hwang, T.C.; Zou, X.
    Molecular modeling of the heterodimer of human CFTRs nucleotide-binding domains using a protein-protein docking approach (2009), J. Mol. Graph. Model., 27, 822-828.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Inhibitors

Inhibitors Comment Organism Structure
genistein bindings of genistein and ATP are competitive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
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 Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens CFTR is a chloride channel whose dysfunction causes cystic fibrosis. The two intracellular nucleotide-binding domains of CFTR control the opening and closing of the channel, structure modelling of the CFTR’s NBD1-NBD2 complex using the NBD crystal structures, overview ADP + phosphate + open Cl- channel
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P13569
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel CFTR is a chloride channel whose dysfunction causes cystic fibrosis. The two intracellular nucleotide-binding domains of CFTR control the opening and closing of the channel, structure modelling of the CFTR’s NBD1-NBD2 complex using the NBD crystal structures, overview Homo sapiens ADP + phosphate + open Cl- channel
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 ?
ATP + H2O + closed Cl- channel binding mode of ATP in the CFTR nucleotide-binding domain NBD1-NBD2 dimer: residue W401 of NBD1 forms ring-ring stacking with the adenine ring of ATP, residues at the NBD2 site that exhibit hydrogen bonding with the second ATP molecule include G1247, S1248, K1250, S1251, T1252 of the Walker A motif of NBD2, Q1291 of the Q-loop of NBD2, T547, S549, and G551 of the signature motif of NBD1. D1370 and E1371 of the Walker B of NBD2 coordinate MgATP, while Y1219 of NBD2 coordinates the adenine ring of ATP through ring-ring stacking Homo sapiens ADP + phosphate + open Cl- channel
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 ?

Subunits

Subunits Comment Organism
More the nucleotide binding sites form a head-to-tail dimer with two ATP-binding sites located at the dimer interface, homology modeling of the nucleotide binding domain 2 based on the crystal structure, PDB code 1XMI, construction of a NBD1-NBD2 heterodimer by protein-protein docking, overview Homo sapiens

Synonyms

Synonyms Comment Organism
CFTR
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 Homo sapiens
cystic fibrosis transmembrane conductance regulator
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 Homo sapiens