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Literature summary for 5.6.1.6 extracted from

  • Aleksandrov, L.; Aleksandrov, A.; Riordan, J.R.
    Mg2+-dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2) (2008), Biochem. J., 416, 129-136.
    View publication on PubMed
Search for more literature for 5.6.1.6

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of wild-type and mutant DELTANBD2 CFTR in BHK-21 cell membranes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of truncation mutant DELTANBD2 CFTR terminating at residue 1172 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
8-azido-ATP is retained at nucleotide-binding domain 1, NBD1 at low temperature even in the absence of bivalent cations Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel Mg2+-dependent ATP occlusion at the first nucleotide-binding domain, NBD1, of CFTR does not require the second, NBD2. ATP binding to the first and second NBDs of CFTR are bivalent-cation-independent and -dependent steps, respectively Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Synonyms

Synonyms Comment Organism
CFTR
-
 Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens