Literature summary for 5.6.1.6 extracted from

Ramjeesingh, M.; Ugwu, F.; Stratford, F.L.; Huan, L.J.; Li, C.; Bear, C.E.
The intact CFTR protein mediates ATPase rather than adenylate kinase activity (2008), Biochem. J., 412, 315-321.

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Protein Variants

Protein Variants	Comment	Organism
E1371Q	low level of residual ATPase activity, no adenylate kinase activity	Homo sapiens
G551D	mutation in ABC signature motif, markedly reduced ATPase activity, no adenylate kinase activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform CFTR	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the isolated nucleotide-binding domains exhibit adenylate kinase activity, while the full-length purified and reconstituted protein functions as a ATPase	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	the isolated nucleotide-binding domains exhibit adenylate kinase activity, while the full-length purified and reconstituted protein functions as a ATPase	Homo sapiens

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Release 2023.1 (January 2023)