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Literature summary for 5.6.1.6 extracted from

  • Hanrahan, J.W.; Wioland, M.A.
    Revisiting cystic fibrosis transmembrane conductance regulator structure and function (2004), Proc. Am. Thorac. Soc., 1, 17-21.
    View publication on PubMed

Application

Application Comment Organism
additional information CFTR is a an ATP-dependent chloride channel, tightly regulated by phosphorylation, two distinct gating modes with one dependent on hydrolysis and the other requiring only stable ATP binding Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
G551D channel does not open in response to phosphorylation by protein kinase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ needed for ATP hydrolysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Rattus norvegicus
-
additional information in secretory serous cells of the submucosal glands of the airway Rattus norvegicus
-
pancreatic duct
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel ATPase activity is much higher at NBD1 than NBD2 of CFTR, ATPase activity is not strictly required for its channel activity Rattus norvegicus ADP + phosphate + open Cl- channel
-
?

Synonyms

Synonyms Comment Organism
CFTR
-
Rattus norvegicus
cystic fibrosis transmembrane conductance regulator
-
Rattus norvegicus