Application | Comment | Organism |
---|---|---|
additional information | CFTR is a an ATP-dependent chloride channel, tightly regulated by phosphorylation, two distinct gating modes with one dependent on hydrolysis and the other requiring only stable ATP binding | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
G551D | channel does not open in response to phosphorylation by protein kinase | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | needed for ATP hydrolysis | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Rattus norvegicus | - |
additional information | in secretory serous cells of the submucosal glands of the airway | Rattus norvegicus | - |
pancreatic duct | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | ATPase activity is much higher at NBD1 than NBD2 of CFTR, ATPase activity is not strictly required for its channel activity | Rattus norvegicus | ADP + phosphate + open Cl- channel | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Rattus norvegicus |
cystic fibrosis transmembrane conductance regulator | - |
Rattus norvegicus |