Application | Comment | Organism |
---|---|---|
additional information | reduced sensitivity to activation by cAMP-dependent protein kinase imparted by Ser 768 may serve to ensure activation of wild type CFTR by strong stimuli while dampening responses to weak signals | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
plasmid pQE60, encoding the CFTR amino acids 645-835 with COOH-terminal 6xHis tag, expressed in Escherichia coli, expression of Flag-wild type CFTR cRNA in Xenopus oocytes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S768A | has higher activity than wild type channels, confirming the inhibitory influence of Ser 768 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by Ni-NTA resin | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |