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Literature summary for 5.6.1.6 extracted from

  • Csanady, L.; Seto-Young, D.; Chan, K.W.; Cenciarelli, C.; Angel, B.B.; Qin, J.; McLachlin, D.T.; Krutchinsky, A.N.; Chait, B.T.; Nairn, A.C.; Gadsby, D.C.
    Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA (2005), J. Gen. Physiol., 125, 171-186.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information reduced sensitivity to activation by cAMP-dependent protein kinase imparted by Ser 768 may serve to ensure activation of wild type CFTR by strong stimuli while dampening responses to weak signals Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
plasmid pQE60, encoding the CFTR amino acids 645-835 with COOH-terminal 6xHis tag, expressed in Escherichia coli, expression of Flag-wild type CFTR cRNA in Xenopus oocytes Homo sapiens

Protein Variants

Protein Variants Comment Organism
S768A has higher activity than wild type channels, confirming the inhibitory influence of Ser 768 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by Ni-NTA resin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
CFTR
-
Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
Homo sapiens