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Literature summary for 5.6.1.6 extracted from

  • Ratner, M.A.; Decker, S.E.; Aller, S.G.; Weber, G.; Forrest, J.N.
    Mercury toxicity in the shark (Squalus acanthias) rectal gland: apical CFTR chloride channels are inhibited by mercuric chloride (2006), J. Exp. Zool. A, 305, 259-267.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
3-isobutyl-1-methylxanthine
-
Squalus acanthias
forskolin
-
Squalus acanthias

Cloned(Commentary)

Cloned (Comment) Organism
expression in Xenopus oocytes Squalus acanthias

Inhibitors

Inhibitors Comment Organism Structure
HgCl2 dose-dependent inhibition of forskolin/3-isobutyl-1-methylxanthine-stimulated chloride secretion, inhibition is maximal when HgCl2 is added before stimulation with forskolin/3-isobutyl-1-methylxanthine, dithiothrietol and glutathione completely prevent inhibition of chloride secretion, inhibits chloride secretion by interacting with the apical membrane Squalus acanthias

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane apical side Squalus acanthias 16020
-

Organism

Organism UniProt Comment Textmining
Squalus acanthias
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
Squalus acanthias
-
rectal gland
-
Squalus acanthias
-

Synonyms

Synonyms Comment Organism
CFTR
-
Squalus acanthias
cystic fibrosis transmembrane conductance regulator
-
Squalus acanthias