Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
stable expressed in CHO cells and transiently transfected in Sf9 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
170000 | - |
1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | Homo sapiens | the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis | ADP + phosphate + open Cl- channel | - |
? | |
additional information | Homo sapiens | the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + closed Cl- channel | - |
Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
ATP + H2O + closed Cl- channel | the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
additional information | the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE | Homo sapiens |
More | enzyme function does not require a multimeric complex for function, reconstituted monomers are sufficient to mediate regulated chloride conduction and ATPase activity | Homo sapiens |
multimer | CFTR exitsts as monomers and multimers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CFTR | - |
Homo sapiens |
cystic fibrosis transmembrane conductance regulator | - |
Homo sapiens |