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Literature summary for 5.6.1.6 extracted from

  • Ramjeesingh, M.; Li, C.; Kogan, I.; Wang, Y.; Huan, L.J.; Bear, C.E.
    A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator (2001), Biochemistry, 40, 10700-10706.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
stable expressed in CHO cells and transiently transfected in Sf9 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis ADP + phosphate + open Cl- channel
-
?
additional information Homo sapiens the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
Homo sapiens ADP + phosphate + open Cl- channel
-
?
ATP + H2O + closed Cl- channel the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis Homo sapiens ADP + phosphate + open Cl- channel
-
?
additional information the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE Homo sapiens
More enzyme function does not require a multimeric complex for function, reconstituted monomers are sufficient to mediate regulated chloride conduction and ATPase activity Homo sapiens
multimer CFTR exitsts as monomers and multimers Homo sapiens

Synonyms

Synonyms Comment Organism
CFTR
-
Homo sapiens
cystic fibrosis transmembrane conductance regulator
-
Homo sapiens