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Literature summary for 5.6.1.6 extracted from

  • Howell, L.D.; Borchardt, R.; Kole, J.; Kaz, A.M.; Randak, C.; Cohn, J.A.
    Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain (2004), Biochem. J., 378, 151-159.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.6

Cloned(Commentary)

Cloned (Comment) Organism
expression of a fusion protein of glutathione S-transferase and nucleotide binding domain 1 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 the MW of the fusion protein of glutathione S-transferase and nucleotide binding domain 1 determined by SDS-PAGE is 70000 Da Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + closed Cl- channel Homo sapiens
-
 ADP + phosphate + open Cl- channel
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein protein kinase A phosphorylates a group of R-domain serine residues in nucleotide binding domain 1. This causes the fusion protein to dimerize, to exhibit cooperative ATP binding and hydrolysis, and to be subject to regulation by nucleotide binding domain 2 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
ATP + H2O + closed Cl- channel protein kinase A phosphorylates a group of R-domain serine residues in nucleotide binding domain 1. This causes the fusion protein to dimerize, to exhibit cooperative ATP binding and hydrolysis, and to be subject to regulation by nucleotide binding domain 2 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?

Subunits

Subunits Comment Organism
More the MW of the fusion protein of glutathione S-transferase and nucleotide binding domain 1 determined by SDS-PAGE is 70000 Da Homo sapiens