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Literature summary for 5.6.1.5 extracted from

  • Snoberger, A.; Brettrager, E.; Smith, D.
    Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing (2018), Nat. Commun., 9, 2374 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-DE3-RIL cells Methanocaldococcus jannaschii

Protein Variants

Protein Variants Comment Organism
M87A the mutant shows almost wild type activity Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Methanocaldococcus jannaschii
-
ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide Methanocaldococcus jannaschii ATCC 43067
-
ADP + phosphate + unfolded polypeptide
-
?
CTP + H2O + polypeptide Methanocaldococcus jannaschii
-
CDP + phosphate + unfolded polypeptide
-
?
CTP + H2O + polypeptide Methanocaldococcus jannaschii ATCC 43067
-
CDP + phosphate + unfolded polypeptide
-
?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii Q58576
-
-
Methanocaldococcus jannaschii ATCC 43067 Q58576
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap Q column chromatography and Superose 12 gel filtration Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
Methanocaldococcus jannaschii ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide
-
Methanocaldococcus jannaschii ATCC 43067 ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide GFPssrA
-
Methanocaldococcus jannaschii ADP + phosphate + unfolded polypeptide GFPssrA
-
?
ATP + H2O + polypeptide GFPssrA
-
Methanocaldococcus jannaschii ATCC 43067 ADP + phosphate + unfolded polypeptide GFPssrA
-
?
CTP + H2O + polypeptide
-
Methanocaldococcus jannaschii CDP + phosphate + unfolded polypeptide
-
?
CTP + H2O + polypeptide
-
Methanocaldococcus jannaschii ATCC 43067 CDP + phosphate + unfolded polypeptide
-
?

Subunits

Subunits Comment Organism
homohexamer
-
Methanocaldococcus jannaschii

Synonyms

Synonyms Comment Organism
AAA+ ATPase
-
Methanocaldococcus jannaschii
PAN
-
Methanocaldococcus jannaschii
proteasomal ATPase
-
Methanocaldococcus jannaschii
Rpt1 subunit Methanocaldococcus jannaschii
Rpt2 subunit Methanocaldococcus jannaschii
Rpt3 subunit Methanocaldococcus jannaschii
Rpt4 subunit Methanocaldococcus jannaschii
Rpt5 subunit Methanocaldococcus jannaschii
Rpt6 subunit Methanocaldococcus jannaschii