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Literature summary for 5.6.1.5 extracted from

  • Takagi, K.; Kim, S.; Yukii, H.; Ueno, M.; Morishita, R.; Endo, Y.; Kato, K.; Tanaka, K.; Saeki, Y.; Mizushima, T.
    Structural basis for specific recognition of Rpt1p, an ATPase subunit of 26 S proteasome, by proteasome-dedicated chaperone Hsm3p (2012), J. Biol. Chem., 287, 12172-12182.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of full-length Hsm3 and the complex with the C-terminal domain of Rpt1 is determined Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
R403A assembly defect of the proteasome is not observed in the single mutant Saccharomyces cerevisiae
R403A/R409A double mutation causes assembly defect of the 26 S proteasome, suggesting that both Arg residues of Rpt1 are responsible for the Hsm3 binding and the proteasome assembly Saccharomyces cerevisiae
R409A assembly defect of the proteasome is not observed in the single mutant Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae a specific interaction between Rpt1 and Hsm3 is required for the proper assembly of the 19 S RP ?
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a specific interaction between Rpt1 and Hsm3 is required for the proper assembly of the 19 S RP Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Rpt1 subunit as part of the 26 S proteasome Saccharomyces cerevisiae