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Literature summary for 5.6.1.5 extracted from

  • Ghee, M.; Melki, R.; Michot, N.; Mallet, J.
    PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly (2005), FEBS J., 272, 4023-4033.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus PA700 prevents fibril formation of both wild-type and A53T alpha-synuclein. It is hypothesized that PA700 sequesters alpha-synuclein oligomeric species that are the precursors of the fibrillar form of the protein, thus preventing its assembly into fibrils ?
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Organism

Organism UniProt Comment Textmining
Bos taurus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PA700 prevents fibril formation of both wild-type and A53T alpha-synuclein. It is hypothesized that PA700 sequesters alpha-synuclein oligomeric species that are the precursors of the fibrillar form of the protein, thus preventing its assembly into fibrils Bos taurus ?
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?

Synonyms

Synonyms Comment Organism
PA700
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Bos taurus