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Literature summary for 5.6.1.5 extracted from
- Phosphorylation of ATPase subunits of the 26S proteasome (1998), FEBS Lett., 430, 269-274.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 6 ATPase subunits of the 26S proteasome cloned | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 700000 | - |
regulatory complex PA700 | Rattus norvegicus |
| 700000 | - |
regulatory complex PA700 | Saccharomyces cerevisiae |
| 700000 | - |
regulatory complex PA700 | Thermoplasma sp. |
| 700000 | - |
proteasome, multicatalytic proteinase complex, central catalytic core | Saccharomyces cerevisiae |
| 700000 | - |
proteasome, multicatalytic proteinase complex, central catalytic core | Thermoplasma sp. |
| 2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Rattus norvegicus |
| 2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Thermoplasma sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? |  |
| ATP + H2O + polypeptide | Rattus norvegicus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Thermoplasma sp. | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
rat | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Thermoplasma sp. | - |
acidophilum | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 26Sproteasome | Thermoplasma sp. |
| recombinant rat SuG1, produced in Escherichia coli | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Rattus norvegicus | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Thermoplasma sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| lung | embryonic lung cell | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Rattus norvegicus | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Thermoplasma sp. | ADP + phosphate + unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 26S proteasome | - |
Homo sapiens |
| 26S proteasome | - |
Rattus norvegicus |
| 26S proteasome | - |
Saccharomyces cerevisiae |
| 26S proteasome | - |
Thermoplasma sp. |
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