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Literature summary for 5.6.1.3 extracted from

  • Kapitein, L.C.; Kwok, B.H.; Weinger, J.S.; Schmidt, C.F.; Kapoor, T.M.; Peterman, E.J.
    Microtubule cross-linking triggers the directional motility of kinesin-5 (2008), J. Cell Biol., 182, 421-428.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis full-length Eg5's motility comprises an unbiased, diffusive mode independent of ATP hydrolysis and a plus end-directed processive mode that requires ATP hydrolysis, Eg5 can switch from diffusive motility to directional motility upon binding to a second microtubule ?
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Xenopus laevis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
Xenopus laevis ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
?
additional information full-length Eg5's motility comprises an unbiased, diffusive mode independent of ATP hydrolysis and a plus end-directed processive mode that requires ATP hydrolysis, Eg5 can switch from diffusive motility to directional motility upon binding to a second microtubule Xenopus laevis ?
-
?

Subunits

Subunits Comment Organism
tetramer a homotetramer-specific diffusive mode keeps full-length Eg5 attached to a microtubule for longer times at near physiological conditions Xenopus laevis

Synonyms

Synonyms Comment Organism
Eg5
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Xenopus laevis
kinesin-5
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Xenopus laevis