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Literature summary for 5.6.1.3 extracted from

  • Kapitein, L.C.; Peterman, E.J.; Kwok, B.H.; Kim, J.H.; Kapoor, T.M.; Schmidt, C.F.
    The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks (2005), Nature, 435, 114-118.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Xenopus sp. kinesin-5 Eg5 drives the sliding of microtubules depending on their relative orientation. Eg5 has the capability of simultaneously moving at about 20 nm/s towards the plus-ends of each of the two microtubules it crosslinks. For anti-parallel microtubules, this results in relative sliding at about 40 nm/s, comparable to spindle pole separation rates in vivo. Eg5 can tether microtubule plus-ends, suggesting an additional microtubule-binding mode for Eg5 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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Organism

Organism UniProt Comment Textmining
Xenopus sp.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n kinesin-5 Eg5 drives the sliding of microtubules depending on their relative orientation. Eg5 has the capability of simultaneously moving at about 20 nm/s towards the plus-ends of each of the two microtubules it crosslinks. For anti-parallel microtubules, this results in relative sliding at about 40 nm/s, comparable to spindle pole separation rates in vivo. Eg5 can tether microtubule plus-ends, suggesting an additional microtubule-binding mode for Eg5 Xenopus sp. ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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Synonyms

Synonyms Comment Organism
kinesin Eg5
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Xenopus sp.