Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-trityl-L-cysteine | tight binding inhibitor, specific for kinesin Eg5. Inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with a IC50 of 500 nM. The S and D-enantiomers of tritylcysteine are nearly equally potent. No inhibition of KIF2A/Kif2 (kinesin-13 family), KIF2C/MCAK (kinesin-13 family), KIF5B/HsuKHC (kinsin-1 family), KIF19/HsCENP-E (kinesin-7 family), KIF20A/HsRabK6 (kinsin-6 family), KIF22A/HsKid (kinesin-10 family), KIF23/HsMKLP1 (kinesin-6 family), KIFC1/HsKIFC1 (kinesin-14 family) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Eg5 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
tight binding inhibitor, specific for kinesin Eg5. Inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with a IC50 of 500 nM. The S and D-enantiomers of tritylcysteine are nearly equally potent. No inhibition of KIF2A/Kif2 (kinesin-13 | Homo sapiens | S-trityl-L-cysteine |