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Literature summary for 5.6.1.3 extracted from

  • Blocker, A.; Severin, F.F.; Burkhardt, J.K.; Bingham, J.B.; Yu, H.; Olivo, J.C.; Schroer, T.A.; Hyman, A.A.; Griffiths, G.
    Molecular requirements for bi-directional movement of phagosomes along microtubules (1997), J. Cell Biol., 137, 113-129.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Mus musculus 5737
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phagosome cytoplasmic kinesin localizes to phagosomes in vivo Mus musculus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Mus musculus the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
J774 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
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 Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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 ?
ATP + H2O + a kinesin associated with a microtubule at position n the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin Mus musculus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?