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Literature summary for 5.6.1.3 extracted from

  • Tomishige, M.; Vale, R.D.
    Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change (2000), J. Cell Biol., 151, 1081-1092.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.3

Cloned(Commentary)

Cloned (Comment) Organism
subcloning of human kinesin K560 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00045
-
 ATP mutant C330/C4 + NEM Homo sapiens
0.00057
-
 ATP mutant C330/C4 Homo sapiens
0.00062
-
 ATP mutant C334/C222 Homo sapiens
0.00084
-
 ATP mutant C334 Homo sapiens
0.00101
-
 ATP wild-type Homo sapiens
0.00119
-
 ATP mutant C337/C344 Homo sapiens
0.0012
-
 ATP mutant C337 Homo sapiens
0.00124
-
 ATP mutant C334 + DTNB Homo sapiens
0.00127
-
 ATP wild-type + DTNB Homo sapiens
0.00151
-
 ATP mutant C334/C222 + NEM, mutant C337/C344 + DTNB Homo sapiens
0.00159
-
 ATP mutant C337 + DTNB Homo sapiens
0.00235
-
 ATP mutant C330/C4 + DTNB Homo sapiens
0.00236
-
 ATP mutant C334/C222 + DTNB Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
microtubule-stimulated ATPase
-
 Homo sapiens