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Literature summary for 5.6.1.3 extracted from

  • Mitchison, T.J.
    The role of microtubule polarity in the movement of kinesin and kinetochores (1986), J. Cell Sci. Suppl., 5, 121-128.
    View publication on PubMed
Search for more literature for 5.6.1.3

Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide
-
 Doryteuthis pealeii
V5+
-
 Doryteuthis pealeii

Localization

Localization Comment Organism GeneOntology No. Textmining
axon
-
 Doryteuthis pealeii 30424
-
cytoplasm axoplasm Doryteuthis pealeii 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
-
 Homo sapiens
120000
-
 predicted polypeptide Doryteuthis pealeii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Strongylocentrotus purpuratus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Strongylocentrotus purpuratus
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Doryteuthis pealeii
-
 squid
-
Homo sapiens
-
 human
-
Strongylocentrotus purpuratus
-
 sea urchin
-

Purification (Commentary)

Purification (Comment) Organism
-
 Doryteuthis pealeii

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Homo sapiens
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Strongylocentrotus purpuratus
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Doryteuthis pealeii
a

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Strongylocentrotus purpuratus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Strongylocentrotus purpuratus GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?