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Literature summary for 5.6.1.2 extracted from
- Characterization of ciliobrevin A mediated dynein ATPase inhibition on flagellar motility of Leishmania donovani (2017), Mol. Biochem. Parasitol., 214, 75-81 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ciliobrevin A | decreases flagellar beat frequency of swimming parasites in a concentration dependent manner. Beat frequency of live and reactivated Leishmania donovani decreases by approximately 89% and 41% respectively in the presence of 0.25 mM ciliobrevin A. This inhibition is lost when ciliobrevin A is removed, suggesting its effects are reversible | Leishmania donovani |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| flagellar axoneme | - |
Leishmania donovani | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | dynein ATPases possibly are responsible for power generation and waveform maintenance of the flagellum of Leishmania donovani | Leishmania donovani |
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