Literature summary for 5.6.1.2 extracted from

Da Costa, R.; Botana, D.; Pinero, S.; Proverbio, F.; Marin, R.
Cadmium inhibits motility, activities of plasma membrane Ca(2+)-ATPase and axonemal dynein-ATPase of human spermatozoa (2016), Andrologia, 48, 464-469 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Cd2+	the enzyme is maximally inhibited by 25 nM free Cd2+ in the assay medium, with a K(50%) inhibition of 11.3 nM Cd2+. The decreased activity of the sperm ATPases might have a critical importance in the biochemical mechanisms underlying the decreased sperm motility of individuals exposed to Cd2+	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
flagellar axoneme	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatozoon	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + a dynein associated with a microtubule at position n	-	Homo sapiens	ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)	-	?

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Release 2023.1 (January 2023)