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Literature summary for 5.6.1.2 extracted from

  • Burakov, A.; Kovalenko, O.; Semenova, I.; Zhapparova, O.; Nadezhdina, E.; Rodionov, V.
    Cytoplasmic dynein is involved in the retention of microtubules at the centrosome in interphase cells (2008), Traffic, 9, 472-480.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
antibody 74.1 monoclonal antibody directed against the dynein intermediate chain. Antibody prevents binding of the dynein intermediate chain to the p150Glued subunit of dynactin and disrupts the dynein-dynactin complex without having an effect on the dynactin structure. Inhibition induces rapid loss of radial microtubule organization, while the levels of key centrososmal proteins or the rates of microtubule nucleation do not change significantly Mus musculus
fragment CC1 fragment of p150Glued subunit of the dynactin complex that corresponds to the coiled coil 1. Fragment prevents binding of the dynein intermediate chain to the p150Glued subunit of dynactin and disrupts the dynein–dynactin complex without having an effect on the dynactin structure. Inhibition induces rapid loss of radial microtubule organization, while the levels of key centrososmal proteins or the rates of microtubule nucleation do not change significantly Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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