Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antibody 74.1 | monoclonal antibody directed against the dynein intermediate chain. Antibody prevents binding of the dynein intermediate chain to the p150Glued subunit of dynactin and disrupts the dynein-dynactin complex without having an effect on the dynactin structure. Inhibition induces rapid loss of radial microtubule organization, while the levels of key centrososmal proteins or the rates of microtubule nucleation do not change significantly | Mus musculus | |
fragment CC1 | fragment of p150Glued subunit of the dynactin complex that corresponds to the coiled coil 1. Fragment prevents binding of the dynein intermediate chain to the p150Glued subunit of dynactin and disrupts the dyneindynactin complex without having an effect on the dynactin structure. Inhibition induces rapid loss of radial microtubule organization, while the levels of key centrososmal proteins or the rates of microtubule nucleation do not change significantly | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
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