Literature summary for 5.6.1.2 extracted from

Shima, T.; Imamula, K.; Kon, T.; Ohkura, R.; Sutoh, K.
Head-head coordination is required for the processive motion of cytoplasmic dynein, an AAA+ molecular motor (2006), J. Struct. Biol., 156, 182-189.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of full-length heavy chain and of 380 kDa truncated heavy chain with N-terminal His-FLAG-biotin tandem tags in Dictyostelium discoideum	Dictyostelium discoideum

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of full-length two-headed heavy chain and of 380 kDa truncated single-head heavy chain. Four to five moelcules of single-headed heavy chain are required for continuous microtubule sliding, while one molecule of two-headed heavy chain is enough for sliding. The two heads of a single full-length dynein communicate with each other to take processive steps along a microtubule	Dictyostelium discoideum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Dictyostelium discoideum	5737	-

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	-	-	-

Subunits

Subunits	Comment	Organism
More	the two heads of a single dynein heavy-chain communicate with each other to take processive steps along a microtubule	Dictyostelium discoideum

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Release 2023.1 (January 2023)