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Literature summary for 5.6.1.2 extracted from

  • Ha, J.; Lo, K.W.; Myers, K.R.; Carr, T.M.; Humsi, M.K.; Rasoul, B.A.; Segal, R.A.; Pfister, K.K.
    A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes (2008), J. Cell Biol., 181, 1027-1039.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression of green fluorescent protein/dynein intermediate chain isoforms fusion proteins in PC12 cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression of green fluorescent protein/dynein intermediate chain isoforms fusion proteins in PC12 cells. Intermediate chain isoforms define dynein populations that are selectively recruited to transport distinct cargoes Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus dynein intermediate chain isoforms define dynein populations that are selectively recruited to transport distinct cargoes. Neurotrophin receptor tyrosine kinase B signaling endosomes are transported by cytoplasmic dynein containing the neuron-specific intermediate chain-1B isoform and not by dynein containing the ubiquitous intermediate chain-2C isoform. Organelles containing tyrosine kinase B also contain dynein with intermediate chain-1 but not intermediate chain-2 isoforms ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information dynein intermediate chain isoforms define dynein populations that are selectively recruited to transport distinct cargoes. Neurotrophin receptor tyrosine kinase B signaling endosomes are transported by cytoplasmic dynein containing the neuron-specific intermediate chain-1B isoform and not by dynein containing the ubiquitous intermediate chain-2C isoform. Organelles containing tyrosine kinase B also contain dynein with intermediate chain-1 but not intermediate chain-2 isoforms Rattus norvegicus ?
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 ?

Subunits

Subunits Comment Organism
More dynein intermediate chain isoforms define dynein populations that are selectively recruited to transport distinct cargoes. Neurotrophin receptor tyrosine kinase B signaling endosomes are transported by cytoplasmic dynein containing the neuron-specific intermediate chain-1B isoform and not by dynein containing the ubiquitous intermediate chain-2C isoform. Organelles containing tyrosine kinase B also contain dynein with intermediate chain-1 but not intermediate chain-2 isoforms Rattus norvegicus