Literature summary for 5.6.1.2 extracted from

Song, C.; Wen, W.; Rayala, S.K.; Chen, M.; Ma, J.; Zhang, M.; Kumar, R.
Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions (2008), J. Biol. Chem., 283, 4004-4013.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HC11 mammary epithelial cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
S88A	phosphorylation-inactive mutant of dynein light chain 1. Overexpression causes apoptosis and accelerated mammary gland involution, with increased levels of Bcl-2 interacting mediator of cell death	Homo sapiens
S88E	phosphorylation mimicking active mutant, inhibits its interaction with the endogenous dynein light chain 1 as well as with Bcl-2 interacting mediator of cell death	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation of dynein light chain 1 at residue S88 by p21-activated kinase disrupts its dimer formation and impairs its interaction with substrate Bcl-2 interacting mediator of cell death	Homo sapiens

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Release 2023.1 (January 2023)