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Literature summary for 5.6.1.2 extracted from

  • Hoshino, M.
    Interactions of Tetrahymena dyneins with microtubule protein. Tubulin-induced stimulation of dynein ATPase activity (1976), Biochim. Biophys. Acta, 462, 49-62.
    View publication on PubMed
Search for more literature for 5.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
tubulin from porcine brain, 3fold increase of 30S dynein activity at pH 10, maximum at a tubulin/30S dynein molar ratio of 10 Tetrahymena pyriformis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 ATP 30S dynein, in the absence of tubulin, 1 mM KCl Tetrahymena pyriformis
0.23
-
 ATP 30S dynein, in the presence of tubulin, 1 mM KCl Tetrahymena pyriformis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n Tetrahymena pyriformis
-
 ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Tetrahymena pyriformis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5
-
 30S dynein, in the presence of tubulin Tetrahymena pyriformis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis AMP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
CTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
GTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis GDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ITP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis IDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
UTP + H2O + a dynein associated with a microtubule at position n
-
 Tetrahymena pyriformis UDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?