Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | ATP hydrolysis completely blocked after preincubation with 2 mM EDTA for 30 min | Homo sapiens | |
VO43- | 60% activity after preincubation with 0.010 mM vanadate for 30 min, vanadate acts as phosphate analog that binds to the gamma-phosphate locus in the ATP-binding site | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.12 | - |
ATP | asthenozoospermic samples | Homo sapiens | |
0.13 | - |
ATP | normozoospermic samples | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a dynein associated with a microtubule at position n | Homo sapiens | - |
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
semen | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.007 | - |
asthenozoospermic samples | Homo sapiens |
0.012 | - |
asthenozoospermic samples, addition of 0.001 mM 5'-(N-ethylcarboxyamido)-adenosine | Homo sapiens |
0.013 | - |
asthenozoospermic samples, addition of 2 mM adenosine | Homo sapiens |
0.013 | - |
asthenozoospermic samples, addition of 2 mM adenosine and 50 microM dipyridamol | Homo sapiens |
0.014 | - |
normozoospermic samples | Homo sapiens |
0.014 | - |
asthenozoospermic samples, addition of 2 mM 2-deoxyadenosine | Homo sapiens |
0.018 | - |
normozoospermic samples, addition of 2 mM adenosine | Homo sapiens |
0.018 | - |
normozoospermic samples, addition of 0.001 mM 5'-(N-ethylcarboxyamido)-adenosine | Homo sapiens |
0.018 | - |
normozoospermic samples, addition of 2 mM adenosine and 0.05 mM dipyridamol | Homo sapiens |
0.019 | - |
normozoospermic samples, addition of 2 mM 2-deoxyadenosine | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a dynein associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? |