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BRENDA support

Literature summary for 5.6.1.2 extracted from

  • Shimizu, T.; Toyoshima, Y.Y.; Edamatsu, M.; Vale, R.D.
    Comparison of the motile and enzymatic properties of two microtubule minus-end-directed motors, ncd and cytoplasmic dynein (1995), Biochemistry, 34, 1575-1582.
    View publication on PubMed
Search for more literature for 5.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
microtubule in presence of microtubule, dynein ATPase activity is stimulated by ca. 6fold Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
AlCl3 1 mM, complete inhibition Bos taurus
vanadate dynein is cleaved by UV-vanadate treatment Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033
-
 ATP
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Bos taurus 5737
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-dideoxy-ATP + H2O + a dynein associated with a microtubule at position n
-
 Bos taurus 2',3'-dideoxy-ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
2'-dATP + H2O + a dynein associated with a microtubule at position n
-
 Bos taurus 2'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
3'-dATP + H2O + a dynein associated with a microtubule at position n
-
 Bos taurus 3'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n
-
 Bos taurus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Bos taurus