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Literature summary for 5.5.1.5 extracted from

  • Thatcher, D.R.; Cain, R.B.
    Metabolism of aromatic compounds by fungi. Kinetic properties and mechanism of 3-carboxy-cis,cis-muconate cyclase from Aspergillus niger (1975), Eur. J. Biochem., 56, 193-204.
    View publication on PubMed

General Stability

General Stability Organism
rose-bengal-sensitized photooxidation Aspergillus niger

Inhibitors

Inhibitors Comment Organism Structure
2-Chloro-4-methylmuconolactone non-competitive Aspergillus niger
3-chloromuconate competitive Aspergillus niger
3-Chloromuconolactone non-competitive Aspergillus niger
3-methylmuconate competitive Aspergillus niger
adipate
-
Aspergillus niger
AsO2-
-
Aspergillus niger
AsO43-
-
Aspergillus niger
BO33- negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum Aspergillus niger
Br-
-
Aspergillus niger
cis-aconitate
-
Aspergillus niger
citraconate
-
Aspergillus niger
citrate
-
Aspergillus niger
ethoxyformic anhydride irreversible, presence of the competitive inhibitors cis-aconitate, trans-aconitate and cis,cis-muconate conferrs some protection Aspergillus niger
F-
-
Aspergillus niger
fumarate
-
Aspergillus niger
glutaconate
-
Aspergillus niger
Glutarate
-
Aspergillus niger
H2PO2- negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum Aspergillus niger
I-
-
Aspergillus niger
Itaconate
-
Aspergillus niger
malate
-
Aspergillus niger
Maleate
-
Aspergillus niger
malonate
-
Aspergillus niger
mesaconate
-
Aspergillus niger
NO2-
-
Aspergillus niger
NO3-
-
Aspergillus niger
oxalate
-
Aspergillus niger
phosphate negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum Aspergillus niger
pimelate
-
Aspergillus niger
S2O32- negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum Aspergillus niger
SO42-
-
Aspergillus niger
succinate
-
Aspergillus niger
Tartrate
-
Aspergillus niger
trans,trans-muconate
-
Aspergillus niger
trans-aconitate
-
Aspergillus niger

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.057
-
3-carboxy-cis,cis-muconate
-
Aspergillus niger

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-Carboxy-cis,cis-muconate
-
Aspergillus niger 3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 6
-
Aspergillus niger