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Literature summary for 5.5.1.4 extracted from

  • Basak, P.; Maitra-Majee, S.; Das, J.K.; Mukherjee, A.; Ghosh Dastidar, S.; Pal Choudhury, P.; Lahiri Majumder, A.
    An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity (2017), PLoS ONE, 12, e0185351 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Oryza sativa

Protein Variants

Protein Variants Comment Organism
DELTAD342 the mutant shows 75% of wild type activity Oryza sativa
DELTAD422 the mutant shows 73% of wild type activity Oryza sativa
DELTAI386 the mutant shows 79% of wild type activity Oryza sativa
DELTAK355/DELTAK359 the mutant shows 7% of wild type activity Oryza sativa
DELTAK359 the mutant shows 59% of wild type activity Oryza sativa
DELTAL346 the mutant shows 90% of wild type activity Oryza sativa
DELTAV384 the mutant shows 59% of wild type activity Oryza sativa
K355A/K359A the mutant shows 14% of wild type activity Oryza sativa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Glucose 6-phosphate Oryza sativa
-
 L-myo-Inositol 1-phosphate
-
 ?
D-glucose 6-phosphate Oryza sativa
-
 1D-myo-inositol 3-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Oryza sativa Q8S5N2
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE Sephacel column chromatography Oryza sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Glucose 6-phosphate
-
 Oryza sativa L-myo-Inositol 1-phosphate
-
 ?
D-glucose 6-phosphate
-
 Oryza sativa 1D-myo-inositol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
D-myo-inositol-3-phosphate synthase
-
 Oryza sativa
L-myo-inositol 1-phosphate synthase
-
 Oryza sativa
MIPS1
-
 Oryza sativa

Cofactor

Cofactor Comment Organism Structure
NAD+ required Oryza sativa