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Literature summary for 5.5.1.4 extracted from
- Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it (2009), Microbiology, 155, 1386-1396.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Cryptococcus neoformans | - |
- |
- |
| Leishmania mexicana | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Mycolicibacterium smegmatis | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Trypanosoma brucei | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glucose 6-phosphate | - |
Saccharomyces cerevisiae | L-myo-Inositol 1-phosphate | - |
? |  |
| D-Glucose 6-phosphate | - |
Mycolicibacterium smegmatis | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Trypanosoma brucei | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Mycobacterium tuberculosis | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Candida albicans | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Leishmania mexicana | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Cryptococcus neoformans | L-myo-Inositol 1-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ino1p | - |
Saccharomyces cerevisiae |
| Ino1p | - |
Mycolicibacterium smegmatis |
| Ino1p | - |
Trypanosoma brucei |
| Ino1p | - |
Mycobacterium tuberculosis |
| Ino1p | - |
Candida albicans |
| Ino1p | - |
Leishmania mexicana |
| Ino1p | - |
Cryptococcus neoformans |
| inositol 3-phosphate synthase | - |
Saccharomyces cerevisiae |
| inositol 3-phosphate synthase | - |
Mycolicibacterium smegmatis |
| inositol 3-phosphate synthase | - |
Trypanosoma brucei |
| inositol 3-phosphate synthase | - |
Mycobacterium tuberculosis |
| inositol 3-phosphate synthase | - |
Candida albicans |
| inositol 3-phosphate synthase | - |
Leishmania mexicana |
| inositol 3-phosphate synthase | - |
Cryptococcus neoformans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharomyces cerevisiae | |
| NAD+ | - |
Mycolicibacterium smegmatis | |
| NAD+ | - |
Trypanosoma brucei | |
| NAD+ | - |
Mycobacterium tuberculosis | |
| NAD+ | - |
Candida albicans | |
| NAD+ | - |
Leishmania mexicana | |
| NAD+ | - |
Cryptococcus neoformans | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages | Mycolicibacterium smegmatis |
| malfunction | the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages | Trypanosoma brucei |
| malfunction | the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages | Mycobacterium tuberculosis |
| malfunction | the inositol 3-phosphate synthase-deficient mutant is not virulent in mice and loses viability in macrophages | Leishmania mexicana |
| malfunction | the inositol 3-phosphate synthase-deficient mutant is virulent in mice as the wild type | Candida albicans |
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