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Literature summary for 5.5.1.4 extracted from
- L-Myo-inositol-1-phosphate synthase from mammalian brain: partial purification and characterisation of the fetal and adult enzyme (1988), Indian J. Biochem. Biophys., 25, 408-412.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | stimulates | Homo sapiens |  |
| NH4+ | stimulates | Rattus norvegicus | |
| NH4+ | between 2.5fold and 3fold stimulation in presence of 12 mM NH4Cl | Homo sapiens | |
| NH4+ | between 2.5fold and 3fold stimulation in presence of 12 mM NH4Cl | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Rattus norvegicus | |
| Hg2+ | - |
Homo sapiens | |
| Hg2+ | - |
Rattus norvegicus | |
| Li+ | - |
Rattus norvegicus | |
| Zn2+ | - |
Homo sapiens | |
| Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.4 | - |
D-glucose 6-phosphate | - |
Homo sapiens | |
| 4.47 | - |
D-glucose 6-phosphate | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | 5 mM KCl stimulates 25-35% | Homo sapiens | |
| K+ | 5 mM KCl stimulates 25-35% | Rattus norvegicus | |
| Na+ | - |
Homo sapiens | |
| Na+ | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 165000 | - |
gel filtration | Homo sapiens |
| 165000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | adult | Rattus norvegicus | - |
| brain | fetal | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glucose 6-phosphate | - |
Homo sapiens | L-myo-Inositol 1-phosphate | - |
? | |
| D-Glucose 6-phosphate | - |
Rattus norvegicus | L-myo-Inositol 1-phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Homo sapiens |
| 7.5 | - |
- |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | cofactor | Homo sapiens | |
| NAD+ | cofactor | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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