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Literature summary for 5.5.1.4 extracted from

  • Rasheed, A.; Corina, D.L.; Barnett, J.E.G.
    Partial reactions of D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase from rat testis (1972), Biochem. J., 126, 15P.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate reaction sequence: 1. Oxidation by NAD+ of C-5 of D-glucose 6-phosphate to give 5-oxo-D-glucose 6-phosphate, 2. aldol condensation between C-6 and C-1 of this molecule to give 1L-myo-inosose-2 1-phosphate, 3. reduction by the NADH first formed to give 1L-myo-inositol 1-phosphate. The NADH and oxidized intermediates are tightly bound Rattus norvegicus
a
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate reaction sequence: 1. oxidation by NAD+ of C-5 of D-glucose 6-phosphate to give 5-oxo-D-glucose 6-phosphate, 2. aldol condensation between C-6 and C-1 of this molecule to give 1L-myoinosose-2 1-phosphate, 3. reduction by the NADH first formed to give 1L-myoinositol 1-phosphate. The NADH and oxidized intermediates are tightly bound Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Glucose 6-phosphate
-
 Rattus norvegicus L-myo-Inositol 1-phosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ Km: 0.05 mM Rattus norvegicus
NAD+ the first partial reaction is the oxidation by NAD+ of C-5 of D-glucose 6-phosphate to give 5-oxo-D-glucose 6-phosphate Rattus norvegicus