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Literature summary for 5.5.1.29 extracted from

  • Nakano, C.; Oshima, M.; Kurashima, N.; Hoshino, T.
    Identification of a new diterpene biosynthetic gene cluster that produces O-methylkolavelool in Herpetosiphon aurantiacus (2015), ChemBioChem, 16, 772-781 .
    View publication on PubMed
Search for more literature for 5.5.1.29

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Herpetosiphon aurantiacus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Herpetosiphon aurantiacus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Herpetosiphon aurantiacus
-
 (+)-kolavenyl diphosphate
-
 ?
geranylgeranyl diphosphate Herpetosiphon aurantiacus DSM 785
-
 (+)-kolavenyl diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Herpetosiphon aurantiacus A9AWD5
-
-
Herpetosiphon aurantiacus DSM 785 A9AWD5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
 Herpetosiphon aurantiacus (+)-kolavenyl diphosphate
-
 ?
geranylgeranyl diphosphate
-
 Herpetosiphon aurantiacus DSM 785 (+)-kolavenyl diphosphate
-
 ?
additional information no substrate: farnesyl diphosphate Herpetosiphon aurantiacus ?
-
 ?
additional information no substrate: farnesyl diphosphate Herpetosiphon aurantiacus DSM 785 ?
-
 ?

Synonyms

Synonyms Comment Organism
Haur_2145
-
 Herpetosiphon aurantiacus

General Information

General Information Comment Organism
physiological function enzyme is a class II diterpene cyclase responsible for the conversion of geranylgeranyl diphosphate into kolavenyl diphosphate. Subsequently, gene product Haur_2146, homologous to Rv3378c, synthesizes (+)-kolavelool through the nucleophilic addition of a water molecule to the incipient cation formed after the diphosphate moiety is released Herpetosiphon aurantiacus