Protein Variants | Comment | Organism |
---|---|---|
A314V | mutation does not change the product outcome | Salvia divinorum |
A314V/F255H | mutation leads to the recovery of the ability to produce (-)-kolavenyl diphosphate of wild-type while retaining the acquired function of forming ent-copalyl diphosphate of mutant F255H | Salvia divinorum |
F255H | mutation in direction to copalyl diphosphate synthase, mutant shows a complete switch of product specificity from (-)-kolavenyl diphosphate to ent-copalyl diphosphate | Salvia divinorum |
V200I | mutation does not change the product outcome | Salvia divinorum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
geranylgeranyl diphosphate | pH 7.0, 30°C | Salvia divinorum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | Salvia divinorum | - |
(-)-kolavenyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salvia divinorum | A0A1S5RW73 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | peltate glandular trichome at abaxial surface and vein | Salvia divinorum | - |
stem | peltate glandular trichome at abaxial surface | Salvia divinorum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate | - |
Salvia divinorum | (-)-kolavenyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KPS | - |
Salvia divinorum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.88 | - |
geranylgeranyl diphosphate | pH 7.0, 30°C | Salvia divinorum |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum. Transient expression in leaves of Nicotiana benthamiana leads to accumulation of (-)-kolavenol | Salvia divinorum |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
470 | - |
geranylgeranyl diphosphate | pH 7.0, 30°C | Salvia divinorum |