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Literature summary for 5.5.1.12 extracted from

  • Zerbe, P.; Chiang, A.; Dullat, H.; ONeil-Johnson, M.; Starks, C.; Hamberger, B.; Bohlmann, J.
    Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare (2014), Plant J., 79, 914-927 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CPS3, phylogenetic analysis and tree, quantitative expression analysis, functional expression of MvCPS3 alone or with MvELS (multifunctional betaalpha-domain class I diterpene synthase) or MvEKS (ent-kaurene synthase) in engineered Nicotiana benthamiana Marrubium vulgare

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Marrubium vulgare
-
(+)-copalyl diphosphate
-
r

Organism

Organism UniProt Comment Textmining
Marrubium vulgare A0A075FA51
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower very low expression level of CPS3 Marrubium vulgare
-
leaf high expression level of CPS3 Marrubium vulgare
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additional information transcript levels of MvCPS3 are 28fold higher in leaves compared with flowers Marrubium vulgare
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
Marrubium vulgare (+)-copalyl diphosphate
-
r
additional information the enzyme shows substrate specificity, reaction product analysis by GC-MS. MvCPS3 does not produce ent-CPP, reaction of EC 5.5.1.13 Marrubium vulgare ?
-
?

Synonyms

Synonyms Comment Organism
(+)-copalyl diphosphate synthase
-
Marrubium vulgare
(+)-CPS
-
Marrubium vulgare
CPS3
-
Marrubium vulgare
MvCPS3
-
Marrubium vulgare

General Information

General Information Comment Organism
evolution diterpene synthases transcriptome analysis of Marrubium vulgare leaves, overview. CPS3 is a class II diterpene synthase, phylogenetic analysis Marrubium vulgare
additional information enzyme CPS3 contains a DIDD functional motif Marrubium vulgare