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Literature summary for 5.5.1.12 extracted from

  • Peters, R.J.; Carter, O.A.; Zhang, Y.; Matthews, B.W.; Croteau, R.B.
    Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations (2003), Biochemistry, 42, 2700-2707.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Abies grandis

Protein Variants

Protein Variants Comment Organism
DELTA:107-868 lower turnover with copalyl diphosphate than wild-type Abies grandis
DELTA:85-849 no turnover with copalyl diphosphate Abies grandis
rAS:D96A nearly the same turnover with copalyl diphosphate like wild-type Abies grandis
rAS:K86A/R87A lower turnover with copalyl diphosphate than wild-type Abies grandis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Abies grandis
-
(+)-copalyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Abies grandis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate
-
Abies grandis (+)-copalyl diphosphate
-
?