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Literature summary for 5.4.99.B22 extracted from

  • Zaganelli, S.; Rebelo-Guiomar, P.; Maundrell, K.; Rozanska, A.; Pierredon, S.; Powell, C.A.; Jourdain, A.A.; Hulo, N.; Lightowlers, R.N.; Chrzanowska-Lightowlers, Z.M.; Minczuk, M.; Martinou, J.C.
    The pseudouridine synthase RPUSD4 is an essential component of mitochondrial RNA granules (2017), J. Biol. Chem., 292, 4519-4532 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.99.B22

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mitochondrial tRNAPhe uridine39 Homo sapiens
-
 mitochondrial tRNAPhe pseudouridine39
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96CM3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitochondrial tRNAPhe uridine39
-
 Homo sapiens mitochondrial tRNAPhe pseudouridine39
-
 ?

Synonyms

Synonyms Comment Organism
RPUSD4
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of RPUSD4 leads to a severe reduction of the steady-state level of the 16S mitochondrial rRNA with defects in the biogenesis of the mitoribosome large subunit and consequently in mitochondrial translation Homo sapiens
metabolism pseudouridine synthase RPUSD4 is an essential component of mitochondrial RNA granules. Several steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modification, are spatially organized into mitochondrial RNA granules Homo sapiens