Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli C43 cells | Klebsiella pneumoniae |
expressed in Escherichia coli C43 cells | Mycobacterium tuberculosis |
expressed in Escherichia coli C43 cells | Deinococcus radiodurans |
Crystallization (Comment) | Organism |
---|---|
in complex with UDP-CH2-Galp, hanging drop vapor diffusion method, using 0.1 M HEPES (pH 6.5), 0.2 M LiCl, and 28% (w/v) polyethylene glycol 6000 | Deinococcus radiodurans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UDP-CH2-Galp | moderate inhibition of UGM | Deinococcus radiodurans | |
UDP-CH2-Galp | moderate inhibition of UGM | Klebsiella pneumoniae | |
UDP-CH2-Galp | moderate inhibition of UGM | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Deinococcus radiodurans | Q9RYF1 | - |
- |
Klebsiella pneumoniae | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Protino Ni-IDA 1000 column chromatography | Klebsiella pneumoniae |
Protino Ni-IDA 1000 column chromatography | Mycobacterium tuberculosis |
Protino Ni-IDA 1000 column chromatography | Deinococcus radiodurans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-galactopyranose | - |
Klebsiella pneumoniae | UDP-alpha-D-galactofuranose | - |
r | |
UDP-alpha-D-galactopyranose | - |
Mycobacterium tuberculosis | UDP-alpha-D-galactofuranose | - |
r | |
UDP-alpha-D-galactopyranose | - |
Deinococcus radiodurans | UDP-alpha-D-galactofuranose | - |
r |
Synonyms | Comment | Organism |
---|---|---|
galactopyranose mutase | - |
Klebsiella pneumoniae |
galactopyranose mutase | - |
Mycobacterium tuberculosis |
galactopyranose mutase | - |
Deinococcus radiodurans |
UGM | - |
Klebsiella pneumoniae |
UGM | - |
Mycobacterium tuberculosis |
UGM | - |
Deinococcus radiodurans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Klebsiella pneumoniae | |
FAD | - |
Mycobacterium tuberculosis | |
FAD | - |
Deinococcus radiodurans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.411 | - |
in 50 mM sodium phosphate buffer (pH 7.0), at 22°C | Deinococcus radiodurans | UDP-CH2-Galp | |
0.479 | - |
in 50 mM sodium phosphate buffer (pH 7.0), at 22°C | Klebsiella pneumoniae | UDP-CH2-Galp | |
0.495 | - |
in 50 mM sodium phosphate buffer (pH 7.0), at 22°C | Mycobacterium tuberculosis | UDP-CH2-Galp |