Literature summary for 5.4.99.7 extracted from

Viola, F.; Brusa, P.; Balliano, G.; Ceruti, M.; Boutaud, O.; Schuber, F.; Cattel, L.
Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives (1995), Biochem. Pharmacol., 50, 787-796.

Search for more literature for 5.4.99.7

Inhibitors

Inhibitors	Comment	Organism	Structure
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide	-	Candida albicans
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide	-	Homo sapiens
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide	-	Rattus norvegicus
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide	-	Saccharomyces cerevisiae
(6E)-10-Aza-10,11-dihydrosqualene-2,3-epoxide	-	Sus scrofa
(6Z)-10-aza-10,11-dihydrosqualene-2,3-epoxide	poor	Sus scrofa
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide	-	Candida albicans
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide	-	Homo sapiens
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide	-	Rattus norvegicus
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide	-	Saccharomyces cerevisiae
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide	noncompetitive	Sus scrofa
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide	-	Candida albicans
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide	-	Homo sapiens
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide	-	Saccharomyces cerevisiae
19-Aza-18,19,22,3-tetrahydrosqualene-2,3-epoxide N-oxide	poor, competitive	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-
Saccharomyces cerevisiae	-	-	-
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-
liver	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-squalene-2,3-epoxide	-	Homo sapiens	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Rattus norvegicus	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Sus scrofa	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Saccharomyces cerevisiae	Lanosterol	-	?
(S)-squalene-2,3-epoxide	-	Candida albicans	Lanosterol	-	?

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Release 2023.1 (January 2023)